What actually works instead
Cloud streaming runs the real Windows build on someone else's machine, so the anti-cheat is satisfied. GeForce NOW has a native Mac app and Xbox Cloud Gaming runs in a browser; both publish the games they carry. And before assuming you need any of this, check whether the game already has a native Mac build — a native build beats translation every time.
Notes
Anti-cheat: Vanguard. Linux/Proton status 'Denied' does not apply to macOS.
Provenance
Are We Anti-Cheat Yet? (MIT) — kernel anti-cheat vendor; structurally impossible under Wine on macOS
Common questions
Does Teamfight Tactics work on Mac?
Yes, but not through a compatibility layer. Riot client ships a native macOS build, and that is what you should install. The Windows build cannot run under Highball, CrossOver, Whisky or a virtual machine, because its anti-cheat needs a Windows kernel driver that macOS will never load.
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